Handel also pointed to the district's pedigree throughout the campaign, urging Republicans not to let Democrats "steal" a seat that became a proxy for the national dynamics in Washington. Ossoff needs a tie there to have a chance of winning, strategists involved in the race say.
The first round of voting last month had delivered a political natural disaster when Jon Ossoff, a 30 year-old former congressional aide and film-maker, came within touching distance of winning the staunchly Republican seat.
If the Republican, Karen Handel, emerges victorious, it will in part reflect the shortcomings of her Democratic opponent, Jon Ossoff. While the Peach State contest has gotten the vast majority of national attention and money, voters in South Carolina's 5th District are also picking who will succeed Trump's Office of Management and Budget Director Mick Mulvaney.
The loss isn't the worst thing for Democrats, but it hurts. In the end, Ossoff lost the seat by six points, more than the margin on Tuesday night in the congressional race in SC to replace Mick Mulvaney, the former House member who is now Trump's budget director. "They need to get used to the idea of no safe seats, because people are fed up".
Democrats were under pressure to win after steadily losing seats in Congress and at the state level in recent years.
There is another election on Tuesday, in SC, but the Republicans are expected to hold the seat, which was vacated when Mick Mulvaney became Mr Trump's budget director.
"It's that fighting spirit, that perseverance and tenacity that I will take to Washington", she said on Tuesday night. A Republican has represented Georgia's 6th Congressional District since 1979.
As skeptical as these generally well-educated Republicans have been about Trump, many were even more reticent to vote for a Democrat - even one who presents as moderately and even-tempered as Ossoff. Handel emphasized that pedigree often during her campaign and again during her victory speech.
But it wasn't what Democrats who pumped $23 million into Ossoff's campaign so desperately craved: A win.
Ossoff took in $8 million from individual contributions, compared to Handel's $2.1.
"This is not the outcome many of us were hoping for", he told supporters. Party organizations, independent political action committees and donors from Los Angeles to Boston sent a cascade of money into a race, filling metro Atlanta's airwaves with ads and its 6th District neighborhoods with hordes of paid canvassers. Even as the United States remains gripped and divided by the drama of the Trump presidency, her victory suggests that all politics is still local.
The Republican victory in Georgia will help calm Republican nerves as the scandals around President Trump deepens.
The Congressional Leadership Fund, the super PAC backed by House leadership, was the first outside group on the ground here.
On policy, she mostly echoes party leaders.
Attorney David Ware said a belief that health care should be affordable determined his vote for Mr Ossoff.