He pulled off some stunning saves at the VEB Arena against CSKA Moscow in the Champions League in midweek and would be hoping to maintain his 100% clean sheet record at Old Trafford this season.
In his nine appearances for United since joining them from Everton over the summer, the Belgium worldwide had scored 10 times, including a brace in Wednesday's 4-1 Champions League victory over CSKA Moscow.
Traditionally, the hosts have always had the edge over their Saturday's rivals with the Red Devils going unbeaten in their last thirteen meetings in all competition. He now has five goals and nine assists this season.
"Unfortunately we have been hit by injuries when we could have done without them", Hodgson told Croydon Advertiser, prior to his side's match at Old Trafford this weekend.
But he has scored a number of key goals for the club and netted an impressive brace in United's 4-0 win over Crystal Palace today. Loftus-Cheek has a thigh strain which he's been battling with for some period of time, which will keep him out of the game.
"I want to see a team that shows the fans that they really care". Pogba, Rojo and Ibrahimovic are all still long term absentees.
"I think Marouane has important qualities and I try to use these qualities depending on the situation".
Manchester United had the flawless start to the match as Marcus Rashford turned past Joel Ward cleverly before driving into the box and picking out Mata who calmly slotted the ball into the bottom corner to open the scoring just three minutes in.
Christian Benteke suffered a knee injury against Manchester City and is likely to sit through next six weeks at least. Timothy Fosu-Mensah is ineligible to play against his parent club and will be unavailable as well.
Fellaini's tally of three league goals so far this season is already more than in the previous two seasons combined.